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Sarcosine, or N -methylglycine, carries the last methyl group of dimethylglycine, which is used to convert THF to 5,10-methylene-THF and produce glycine [77]

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Understanding these metabolic distinctions is crucial for comprehending why TAMs exert profound control over ferroptosis and how their reprogrammed immunometabolic states can influence tumor progression and therapeutic response, as shown in Figure 1